{"id":3894,"date":"2021-05-08T04:09:58","date_gmt":"2021-05-07T20:09:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894"},"modified":"2021-05-08T04:09:58","modified_gmt":"2021-05-07T20:09:58","slug":"introduction-of-a-new-synthetic-route-about-4-bromo-1-methyl-1h-pyrazole-5-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894","title":{"rendered":"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde"},"content":{"rendered":"

Reference of 473528-88-0<\/a>,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

A mixture of 8-1 (700 mg, 3.7 mmol), bis(pinacolato)diboron (1.1 g, 4.4 mmol), Pd(dppf)Cl2 (190 mg, 0.26 mmol) and AcOK (1.1 g, 11.1 mmol) in dioxane (25 mL) was stirred at 105 C overnight under nitrogen atmosphere. After cooling to room temperature, the mixture was evaporated to remove most of dioxane. The residue was treated with brine (30 mL) and extracted with EtOAc (40 mL*2). The combined organic layers were dried over Na2SO4 and filtered. The filtrated was concentrated to give the crude title compound as a black oil (2.9 g).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[335,131],"tags":[126],"class_list":["post-3894","post","type-post","status-publish","format-standard","hentry","category-473528-88-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde<\/title>\n<meta name=\"description\" content=\"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde\" \/>\n<meta property=\"og:description\" content=\"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-07T20:09:58+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894\",\"name\":\"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-07T20:09:58+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3894#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde","description":"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894","og_locale":"en_US","og_type":"article","og_title":"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde","og_description":"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-05-07T20:09:58+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894","name":"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-05-07T20:09:58+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=3894"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3894#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Introduction of a new synthetic route about 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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