{"id":3887,"date":"2021-05-08T04:09:11","date_gmt":"2021-05-07T20:09:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3887"},"modified":"2021-05-08T04:09:11","modified_gmt":"2021-05-07T20:09:11","slug":"simple-exploration-of-5-4-chlorophenyl-1-24-dichlorophenyl-4-methylpyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3887","title":{"rendered":"Simple exploration of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  162758-35-2, <a href=\"https:\/\/www.ambeed.com\/products\/162758-35-2.html\">category: pyrazoles-derivatives<\/a><\/p>\n<p>General procedure: To a solution of the carboxylic acid (1 eq) in dry dichloromethane, was added N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDC.HCl, 1.2 eq), Hydroxybenzotriazole (1.2 eq) and diisopropylethyl amine (3 eq) at 0C. Then the amine (1.1 eq) was added and stirred at RT for 6h. To the reaction mixture, water was added and the organic layer was separated, washed with saturated NaHCO3, 1N HCl, dried over Na2SO4 and concentrated under reduced pressure. This crude mixture was purified by column chromatography to give the pure compound.<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,131],"tags":[167],"class_list":["post-3887","post","type-post","status-publish","format-standard","hentry","category-162758-35-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Simple exploration of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Simple exploration of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid","description":"Adding a certain compound to certain chemical reactions, such as: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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