{"id":3854,"date":"2021-05-07T03:17:51","date_gmt":"2021-05-06T19:17:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3854"},"modified":"2021-05-07T03:17:51","modified_gmt":"2021-05-06T19:17:51","slug":"share-a-compound-2-5-methyl-3-trifluoromethyl-1h-pyrazol-1-ylacetic-acid-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3854","title":{"rendered":"Share a compound : 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid"},"content":{"rendered":"

Application of 345637-71-0<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 345637-71-0 name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

Step F: Preparation of 1-[4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone To a solution of 1-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]piperazine hydrochloride (i.e. the product of Example 7, Step E) (200 mg, 0.57 mmol) and 5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetic acid (0.120 g, 0.57 mmol) in dichloromethane (10 mL) at room temperature was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.110 g, 0.57 mmol), triethylamine (0.086 g, 0.85 mmol) and 1-hydroxy-benzotriazole hydrate (0.020 g, 0.14 mmol). The reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with dichloromethane (30 mL) and washed with water (20 mL) and brine (20 mL). The organic layer was dried (Na2SO4) and concentrated under reduced pressure. The crude residue was purified by column chromatography using 3% methanol in chloroform as eluant to give 180 mg of the title product as a white solid. 1H NMR (CDCl3): delta 2.32 (s, 3H), 3.29 (m, 1H), 3.52 (m, 2H), 3.61 (m, 2H), 3.79-3.72 (m, 5H), 4.98 (m, 2H), 5.69 (m,1H), 6.33 (s, 1H), 6.93 (s, 1H), 7.38-7.28 (m, 5H). Mass spectrum at 505.5 (M+1).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[329,131],"tags":[127],"class_list":["post-3854","post","type-post","status-publish","format-standard","hentry","category-345637-71-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nShare a compound : 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid<\/title>\n<meta name=\"description\" content=\"Application of 345637-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 345637-71-0 name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3854\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid\" \/>\n<meta property=\"og:description\" content=\"Application of 345637-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 345637-71-0 name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=3854","og_locale":"en_US","og_type":"article","og_title":"Share a compound : 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid","og_description":"Application of 345637-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 345637-71-0 name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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