{"id":3838,"date":"2021-05-07T03:17:51","date_gmt":"2021-05-06T19:17:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3838"},"modified":"2021-05-07T03:17:51","modified_gmt":"2021-05-06T19:17:51","slug":"discovery-of-3-bromo-1-methyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3838","title":{"rendered":"Discovery of 3-Bromo-1-methyl-1H-pyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 3-Bromo-1-methyl-1H-pyrazole<\/a><\/p>\n

A mixture of l-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)-6-((4- methoxybenzyl)oxy)-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-indazole (3.0 g, 5.0 mmol, 1.0 eq), 3-bromo-l-methyl-lH-pyrazole (151049-87-5) (880 mg, 5.5 mmol, 1.1 eq) and K2C03 (1.38 g, 10.0 mmol, 2.0 eq) in 1, 4-dioxane\/H20 (100 mL\/5 mL) was stirred while purging N2 at rt for 10 min. To this system was added Pd(dppf)Cl2 (458 mg, 0.5 mmol, 0.1 eq) and heated to 110 C for 16 h. The mixture was diluted with EA (100 mL) and washed with saturated aqueous NaHC03 solution (100 mL) and brine (100 mL). The organics were dried (Na2S04) and concentrated in vacuo. The crude mixture was purified by silica gel chromatography using PE\/EA (1\/1) as eluent to give l-(6-(((tert- butyldimethylsilyl)oxy)methyl)pyridin-2-yl)-6-((4-methoxybenzyl)oxy)-4-(l-methyl-lH- pyrazol-3-yl)-lH-indazole. 1.75 g, as a yellow solid, Y: 62%. ESI-MS (M+H) +: 556.2.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[331,131],"tags":[126],"class_list":["post-3838","post","type-post","status-publish","format-standard","hentry","category-151049-87-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 3-Bromo-1-methyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 3-Bromo-1-methyl-1H-pyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3838\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of 3-Bromo-1-methyl-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Discovery of 3-Bromo-1-methyl-1H-pyrazole","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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