{"id":3835,"date":"2021-05-06T04:36:13","date_gmt":"2021-05-05T20:36:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3835"},"modified":"2021-05-06T04:36:13","modified_gmt":"2021-05-05T20:36:13","slug":"a-new-synthetic-route-of-3-methyl-1h-pyrazol-5-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3835","title":{"rendered":"A new synthetic route of 3-Methyl-1H-pyrazol-5-amine"},"content":{"rendered":"

Related Products of 113402-89-4<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113402-89-4 as follows.<\/p>\n

Will 10mmol compound 1,10 mmol of compound 2 and 1 mmol of K2CO3 and 10 mL of PEG 400 were added to the reaction flask.Reaction at 80 \u00b0 C for 24 h,The reaction solution was cooled to room temperature.Precipitating in ether,The filtrate was collected by filtration.Purified by gel chromatography (mobile phase petroleum ether \/ ethyl acetate = 5:1),Compound 3;Compound 3 (1 mmol),Raney Nickel (0.1g),Sodium n-propoxide (0.92 g, 11 mmol) was dissolved in 50 mL of 1,2-dimethoxyethane.Reaction at 60 \u00b0 C for 10 h,Cool to room temperature,Collect organic phase by filtration,Removal of 1,2-dimethoxyethane by rotary evaporation,The compound 62 was purified by column chromatography using acetonitrile \/ dichloromethane (5:1 by volume).<\/p>\n

According to the analysis of related databases, 113402-89-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 113402-89-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[597,131],"tags":[145],"class_list":["post-3835","post","type-post","status-publish","format-standard","hentry","category-113402-89-4","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new synthetic route of 3-Methyl-1H-pyrazol-5-amine<\/title>\n<meta name=\"description\" content=\"Related Products of 113402-89-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113402-89-4 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3835\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 3-Methyl-1H-pyrazol-5-amine\" \/>\n<meta property=\"og:description\" content=\"Related Products of 113402-89-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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