{"id":3831,"date":"2021-05-06T04:36:13","date_gmt":"2021-05-05T20:36:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3831"},"modified":"2021-05-06T04:36:13","modified_gmt":"2021-05-05T20:36:13","slug":"simple-exploration-of-4-fluoro-1h-pyrazole-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3831","title":{"rendered":"Simple exploration of 4-Fluoro-1H-pyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. SDS of cas: 35277-02-2<\/a><\/p>\n

Step 1 : Benzyl 1-(4-fluoro-1 H-pyrazol-1 -yl)cyclopropanecarboxylate To a solution of 4-fluoropyrazole (125 mg, 1.45 mmol) in tetrahydrofuran (4 mL) at 0C was added sodium hydride (60% suspension in mineral oil, 1 16 mg, 2.90 mmol). The mixture was stirred at 0C for 40 min before benzyl 2,4-dibromobutyrate (0.30 mL, 1.50 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organics were dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified via flash chromatography to afford benzyl 1-(4-fluoro-1 \/-\/-pyrazol-1-yl)cyclopropanecarboxylate as a clear oil (1 15 mg, 30.4%). 1H NMR (400 MHz, CDCI3) delta 1.64-1.70 (m, 2H), 1.81 -1.86 (m, 2H), 5.14 (s, 2H), 7.22-7.26 (m, 2H), 7.31-7.36 (m, 3H), 7.40 (td, 2H).<\/p>\n

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[161,131],"tags":[145],"class_list":["post-3831","post","type-post","status-publish","format-standard","hentry","category-35277-02-2","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSimple exploration of 4-Fluoro-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. 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