{"id":3819,"date":"2021-05-06T04:36:13","date_gmt":"2021-05-05T20:36:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3819"},"modified":"2021-05-06T04:36:13","modified_gmt":"2021-05-05T20:36:13","slug":"extracurricular-laboratory-synthetic-route-of-5-iodo-1-methyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3819","title":{"rendered":"Extracurricular laboratory: Synthetic route of 5-Iodo-1-methyl-1H-pyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 34091-51-5<\/a><\/p>\n

Production Example 18 1′-(4-Fluorophenyl)-2-methyl-1’H,2H-3,4′-bipyrazole Under a nitrogen atmosphere, a mixture of 5-iodo-1-methyl-1H-pyrazole (600 mg), [1-(4-fluorophenyl)-1H-pyrazol-4-yl]boronic acid (650 mg), tetrakistriphenylphosphine palladium (166 mg), 2 M sodium carbonate aqueous solution (2.9 mL), ethanol (3.0 mL) and toluene (6.0 mL) was stirred at 100 C. for 4 hours. Thereafter, water was added to the reaction solution, and the obtained mixture was then extracted with ethyl acetate. The organic layer was concentrated under a reduced pressure, and the residue was then purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=9:1 to ethyl acetate), so as to obtain the title compound (450 mg) in the form of a light yellow solid. 1H NMR (600 MHz, CHLOROFORM-d) delta ppm 3.97 (s, 3H) 6.34 (d, J=1.83 Hz, 1H) 7.14-7.22 (m, 2H) 7.46-7.53 (m, 1H) 7.66-7.72 (m, 2H) 7.83 (s, 1H) 7.98 (s, 1H); MS (ESI pos.) m\/z: 243 [M+H]+<\/p>\n

The synthetic route of 34091-51-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 34091-51-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[273,131],"tags":[127],"class_list":["post-3819","post","type-post","status-publish","format-standard","hentry","category-34091-51-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 5-Iodo-1-methyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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