{"id":3817,"date":"2021-05-06T04:36:13","date_gmt":"2021-05-05T20:36:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3817"},"modified":"2021-05-06T04:36:13","modified_gmt":"2021-05-05T20:36:13","slug":"new-downstream-synthetic-route-of-1h-pyrazole-35-dicarboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3817","title":{"rendered":"New downstream synthetic route of 1H-Pyrazole-3,5-dicarboxylic acid"},"content":{"rendered":"

3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1H-Pyrazole-3,5-dicarboxylic acid<\/a><\/p>\n

Example 20: 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid methyl ester(i) 1H-Pyrazole-3,5-dicarboxylic acid dimethyl ester To 12 g of 1H-Pyrazole-3,5-dicarboxylic acid 100 ml HCl in methanol (8M) were added at RT and stirred for 48h. Then the solvents were removed under reduced pressure and the residue codestilled with toluene (2X50 ml). Yield: 14g.<\/p>\n

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[140,131],"tags":[126],"class_list":["post-3817","post","type-post","status-publish","format-standard","hentry","category-3112-31-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 1H-Pyrazole-3,5-dicarboxylic acid<\/title>\n<meta name=\"description\" content=\"3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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