{"id":3814,"date":"2021-05-06T04:35:33","date_gmt":"2021-05-05T20:35:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3814"},"modified":"2021-05-06T04:35:33","modified_gmt":"2021-05-05T20:35:33","slug":"the-important-role-of-4-bromo-3-methyl-5-trifluoromethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3814","title":{"rendered":"The important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole"},"content":{"rendered":"

Related Products of 60061-68-9<\/a>, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

EXAMPLE 37; [4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-vfl-phenviyacetonitrile; 37A. 4-Bromo-5-methyl-1 -(tetrahvdro-pyran-2-yl)-3-trifluoromethyl-1 H-pyrazole; To a solution of 4-bromo-5-methyl-3-trif.uorornethy.-1 H-pyrazole (1.4g, 6.2mmol, LOequiv) in chloroform (31ml) was added p-toluene sulphonic acid monohydrate (118mg, 0.62mmol, O.iequiv). The solution was cooled to EPO O0C and 3,4-dihydro-2H-pyran (0.85ml, 9.3mmol, 1.5equiv) was added drop-wise over 5 minutes. The mixture was allowed to warm to room temperature for 1 hour and the solvents were removed under reduced pressure. The crude mixture was purified by column chromatography (Sitheta2), eluting with 0->25% EtOAc-petrol over a linear gradient to afford the title compound 1.4 g (59%), LCMS (PS-A) R1 3.72 min [M+H]+ 314.<\/p>\n

The synthetic route of 60061-68-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 60061-68-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[536,131],"tags":[127],"class_list":["post-3814","post","type-post","status-publish","format-standard","hentry","category-60061-68-9","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nThe important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Related Products of 60061-68-9, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Related Products of 60061-68-9, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-05T20:35:33+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814\",\"name\":\"The important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-05T20:35:33+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 60061-68-9, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3814#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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