{"id":3804,"date":"2021-05-06T04:35:33","date_gmt":"2021-05-05T20:35:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3804"},"modified":"2021-05-06T04:35:33","modified_gmt":"2021-05-05T20:35:33","slug":"the-important-role-of-1-1h-pyrazol-4-ylethanone","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3804","title":{"rendered":"The important role of 1-(1H-Pyrazol-4-yl)ethanone"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, A new synthetic method of this compound is introduced below., Formula: C5H6N2O<\/a><\/p>\n

2-Chloro-N-[(dimethylamino)methylene]-5-nitrobenzenesulfonamide (2.02 g, 6.94 mmol) and 1-(1H-pyrazol-4-yl)ethanone (1.00 g, 10.4 mmol) were dissolved in acetonitrile,powdered potassium carbonate (2.88 g, 20.8 mmol) was added and the reaction mixture was stirred at 10000 overnight. Then, it was concentrated in vacuo and was extracted with dichioromethane\/water. The organic phase was washed again with brine, followed by drying over sodium sulfate and concentration in vacuo.As the protection group was partly lost, it was redissolved in DMF (6.6 mL) and 1,1- dimethoxy-N,N-dimethylmethanamine (0.882 g, 7.4 mmol) was added. It was stirred overnight, concentrated in vacuo and extracted with dichloromethane\/water. The organic phase was washed again with brine, followed by drying over sodium sulfate and concentration in vacuo to provide 1 .3 g of crude N-[(dimethylamino)methylene]-2-(3-formyl-1 H-pyrazol-1-yl)-5-nitrobenzenesulfonamide.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[460,131],"tags":[126],"class_list":["post-3804","post","type-post","status-publish","format-standard","hentry","category-25016-16-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 1-(1H-Pyrazol-4-yl)ethanone<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, A new synthetic method of this compound is introduced below., Formula: C5H6N2O\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3804\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 1-(1H-Pyrazol-4-yl)ethanone\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 1-(1H-Pyrazol-4-yl)ethanone","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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