{"id":3794,"date":"2021-05-06T04:34:47","date_gmt":"2021-05-05T20:34:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3794"},"modified":"2021-05-06T04:34:47","modified_gmt":"2021-05-05T20:34:47","slug":"the-origin-of-a-common-compound-about-1-tetrahydro-2h-pyran-4-yl-1h-pyrazol-4-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3794","title":{"rendered":"The origin of a common compound about 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine<\/a><\/p>\n

General procedure: [00495] A mixture of 2-chloro-N-(( 1 r,4r)-4-morpholinocyclohexyl)-5 -phenyl-7-tosyl-7H-pyrrolo [2,3 – djpyrimidin-4-amine (79 mg, 0.14 mmol, 1.0 eq), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine 9 (49mg, 0.30 mmol, 2.3 eq), and trifluoroacetic acid (0.20 mL, 2.6 mmol, 19 eq) in 2.0 mL of isopropanol was heated at 120 C in a capped vial for 4 hr. The reaction mixture was cooled to room temperature and purified on reverse phase HPLC giving N4-(( 1 r,4r)-4-morpholinocyclohexyl)-5 -phenyl-N2-( 1 -(tetrahydro-2H-pyran- 4-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-djpyrimidine-2,4-diamine as a white powder after lyophilization (1.9 mg, 2% yield). LC-MS: M+H=543.3. Also isolated 30 mg of beige solid as N4-((lr,4r)-4- morpholinocyclohexyl)-5 -phenyl-N2-(1 -(tetrahydro-2H-pyran-4-yl)- 1H-pyrazol-4-yl)-7-tosyl-7H- pyrrolo [2,3 -djpyrimidine-2,4-diamine (31% yield).<\/p>\n

According to the analysis of related databases, 1190380-49-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1190380-49-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-3794","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3794\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The origin of a common compound about 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine","description":"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=3794","og_locale":"en_US","og_type":"article","og_title":"The origin of a common compound about 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine","og_description":"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. 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