{"id":3793,"date":"2021-05-06T04:34:47","date_gmt":"2021-05-05T20:34:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3793"},"modified":"2021-05-06T04:34:47","modified_gmt":"2021-05-05T20:34:47","slug":"new-learning-discoveries-about-2-4-fluoro-1h-pyrazol-1-ylethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3793","title":{"rendered":"New learning discoveries about 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol"},"content":{"rendered":"

Some common heterocyclic compound, 1207961-59-8, name is 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H7FN2O<\/a><\/p>\n

Methanesulfonyl chloride (16.8 g, 11.4 mL, 147 mmol) was added to a solution of compound 6a (13.4 g, 98 mmol), diisopropylamine (34.3 mL, 196 mmol), and 4-(dimethylamino)-pyridine (1.2 g, 9.78 mmol) in dichloromethane (245 mL) in an ice bath. The reaction was warm to room temperature and stirred at room temperature for 2 h. Water (50 mL) was added to quench the reaction. The organic layer was dried, filtered, and concentrated to get a brown oil. This oil residue was purified by silica gel chromatography (0?60% EtOAc in hexane) to give compound 6b (19.5 g, 96% yield) as a yellowish oil. 1H NMR (400 MHz, CDCl3-d) delta ppm 2.89 (s, 3H), 4.33-4.38 (m, 2H), 4.53-4.59 (m, 2H), 7.38 (d, J=1.52 Hz, 1H), 7.40 (d, J=1.01 Hz, 1H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1207961-59-8, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1207961-59-8, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[592,131],"tags":[126],"class_list":["post-3793","post","type-post","status-publish","format-standard","hentry","category-1207961-59-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 1207961-59-8, name is 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H7FN2O\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3793\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New learning discoveries about 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 1207961-59-8, name is 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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