{"id":3790,"date":"2021-05-06T04:34:47","date_gmt":"2021-05-05T20:34:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3790"},"modified":"2021-05-06T04:34:47","modified_gmt":"2021-05-05T20:34:47","slug":"a-new-synthetic-route-of-5-amino-13-dimethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3790","title":{"rendered":"A new synthetic route of 5-Amino-1,3-dimethylpyrazole"},"content":{"rendered":"

Synthetic Route of 3524-32-1<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

Example 16The appropriate pyrazole amine (0.36 mmol), palladium(II) acetate (5.43 mg, 0.02 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (28.0 mg, 0.05 mmol) and cesium carbonate (118 mg, 0.36 mmol) were weighed out in a microwave vial and sealed. 2-[[2-chloro-5-(trifluoromethyl)-4-pyridyl]amino]-5-fluoro-N-methoxybenzamide (110 mg, 0.30 mmol) dissolved in dioxane (4 mL) was added and argon was bubbled through the mixture for 5 minutes. The resulting mixture was stirred at 95 0C. The reaction mixture was allowed to cool to room temperature, silica gel was added and the mixture was concentrated to afford the crude product, was purified by flash chromatography on silica gel eluting with 0 to 5% MeOH in EtOAc\/DCM (1 :1). The solvent was evaporated to dryness, the resulting gummy residue was triturated in a specified solvent, collected by filtration and dried to afford the desired compound as a solid. Example 16.012- [ [2- [(2,5-dimethylpyr azol-3-yl)aminol -5-(trifluoromethyl)-4-pyridyll aminol -5- fluoro-N-methoxy-benzamide This compound was prepared using l,3-dimethylpyrazole-5-amine. Heating time:2 hours; triturated in tBuOMe\/pentane (1 :1); 55 mg, 39%; NMR Spectrum: (DMSOd6) 2.07 (s, 3H), 3.53 (s, 3H), 3.58 (s, 3H), 5.98 (s, IH), 5.49 (s, IH), 7.42 (dd. IH), 7.46 (dd, IH), 7.60 (dd, IH), 8.22 (s, IH), 8.96 (s, IH), 9.20 (bs, IH), 11.94 (bs, zlH); Mass spectrum: MH+ 439<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1,3-dimethylpyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1,3-dimethylpyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[139,131],"tags":[126],"class_list":["post-3790","post","type-post","status-publish","format-standard","hentry","category-3524-32-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of 5-Amino-1,3-dimethylpyrazole<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 3524-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3790\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 5-Amino-1,3-dimethylpyrazole\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 3524-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of 5-Amino-1,3-dimethylpyrazole","description":"Synthetic Route of 3524-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=3790","og_locale":"en_US","og_type":"article","og_title":"A new synthetic route of 5-Amino-1,3-dimethylpyrazole","og_description":"Synthetic Route of 3524-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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