{"id":3789,"date":"2021-05-06T04:34:47","date_gmt":"2021-05-05T20:34:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3789"},"modified":"2021-05-06T04:34:47","modified_gmt":"2021-05-05T20:34:47","slug":"the-important-role-of-13-dimethyl-1h-pyrazol-4-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3789","title":{"rendered":"The important role of 1,3-Dimethyl-1H-pyrazol-4-amine"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives<\/a><\/p>\n

Example 4.128- [ [2- [(1 ,3-Dimethylpyrazol-4-yl)aminol -5-fluor o-4-pyridyll aminol -2-methyl-3,4- dihydroisog uinolin- 1-one A mixture of 8-[(2-chloro-5-fluoropyridin-4-yl)amino]-2-methyl-3,4- dihydroisoquinolin- 1-one (100 mg, 0.33 mmol), l,3-dimethylpyrazol-4-amine (48 mg, 0.43 mmol), sodium tert-butoxide (51.5 mg, 0.54 mmol) and 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (41.4 mg, 0.07 mmol) in anhydrous dioxane (3 mL) was degassed with nitrogen and then bis(dibenzylideneacetone)palladium (32.7 mg, 0.057 mmol) was added. The mixture was heated at 15O0C for 30 minutes in a microwave reactor. MeOH was added and the mixture loaded onto an SCX column. The product was eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated. The residue was purified by preparative HPLC and fractions containing product were combined and evaporated to afford example 4.12 (50.1 mg, 40% yield); 1H NMR spectrum (300 MHz, DMSO): delta 2.09 (3H, s), 2.95 (2H, t), 3.05 (3H, s), 3.55 (2H, t), 3.70 (3H, s), 6.83 – 6.85 (2H, m), 7.38 – 7.43 (2H, m), 7.85 (IH, s), 7.89 (2H, t), 11.24 (IH, s); Mass spectrum: m\/z (ESI+) (M+H)+ = 381.56.<\/p>\n

According to the analysis of related databases, 64517-88-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 64517-88-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[383,131],"tags":[126],"class_list":["post-3789","post","type-post","status-publish","format-standard","hentry","category-64517-88-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 1,3-Dimethyl-1H-pyrazol-4-amine<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3789\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 1,3-Dimethyl-1H-pyrazol-4-amine\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. 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