{"id":3730,"date":"2021-04-29T04:42:03","date_gmt":"2021-04-28T20:42:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3730"},"modified":"2021-04-29T04:42:03","modified_gmt":"2021-04-28T20:42:03","slug":"the-important-role-of-5-amino-1h-pyrazole-3-acetic-acid-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3730","title":{"rendered":"The important role of 5-Amino-1H-pyrazole-3-acetic acid"},"content":{"rendered":"

Synthetic Route of 174891-10-2<\/a>,Some common heterocyclic compound, 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

7-(Benzyloxy)-4-chloroquinazoline (1.0 g, 3.70 mmol) was dissolved in acetic acid (6 mL) and 3-amino-1H-pyrazole-5-acetic acid (0.78 g, 5.56 mmol).The temperature was raised to 100 C for 2.5 hours. The reaction was stopped, the temperature was lowered to room temperature, and after a large amount of solid was precipitated, it was filtered, and the filter cake was rinsed with a small amount of acetic acid (3 mL), and ethyl acetate (10 mL) was rinsed, and dried under vacuum at 60 C under vacuum.A pink solid (1.28 g, 92.09%) was obtained.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1H-pyrazole-3-acetic acid, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1H-pyrazole-3-acetic acid, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[350,131],"tags":[126],"class_list":["post-3730","post","type-post","status-publish","format-standard","hentry","category-174891-10-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 5-Amino-1H-pyrazole-3-acetic acid<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 174891-10-2,Some common heterocyclic compound, 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 5-Amino-1H-pyrazole-3-acetic acid\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 174891-10-2,Some common heterocyclic compound, 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-28T20:42:03+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730\",\"name\":\"The important role of 5-Amino-1H-pyrazole-3-acetic acid\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-28T20:42:03+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 174891-10-2,Some common heterocyclic compound, 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3730#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 5-Amino-1H-pyrazole-3-acetic acid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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