{"id":3718,"date":"2021-04-29T04:42:03","date_gmt":"2021-04-28T20:42:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3718"},"modified":"2021-04-29T04:42:03","modified_gmt":"2021-04-28T20:42:03","slug":"share-a-compound-1-methyl-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3718","title":{"rendered":"Share a compound : 1-Methyl-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

These common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 25016-20-0<\/a><\/p>\n

Step 1: Preparation ofmethyl 1-methyl-JH-pyrazole-3-carboxylate. To a solution of i-methyl1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOC12 (1.4 mL, 20 mmol) at 0C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed withsatd. aq. NaHCO3and concentrated to afford methyl 1 -methyl-1H-pyrazole-3-carboxylate.LC-MS: m\/z 141 (M+H).<\/p>\n

The synthetic route of 1-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[242,131],"tags":[126],"class_list":["post-3718","post","type-post","status-publish","format-standard","hentry","category-25016-20-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 1-Methyl-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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