{"id":3717,"date":"2021-04-29T04:42:03","date_gmt":"2021-04-28T20:42:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3717"},"modified":"2021-04-29T04:42:03","modified_gmt":"2021-04-28T20:42:03","slug":"new-learning-discoveries-about-5-furan-2-yl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3717","title":{"rendered":"New learning discoveries about 5-(Furan-2-yl)-1H-pyrazol-3-amine"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Product Details of 96799-02-9<\/a><\/p>\n

To a solution of compound 2 (300 mg, 0.88 mmol) in THF (5 mL) a solution of 3- amino-5-92-furyl)pyrazole (105 mg, 0.70 mmol) and DIPEA (0.16 mL, 0.88 mmol) was added in 10-20 mL microwave vial. Vial was sealed with a cap and the mixture was allowed to stir at 150 0C for 5 minutes in the microwave synthesizer. Next, 1 -methyl piperazine (0.15 mL, 1.32 mmol) and DIPEA (0.23 mL, 1.32 mmol) were added to the above mixture and allowed to stir at 60 0C for 10 min. in the microwave synthesizer. The solvents were evaporated and the residue was chromatographed on a silica gel column eluted with 0-5 % MeOH\/DCM obtaining compound 5 as off white solid (120 mg, 26 %). 1H NMR (400 MHz, DMSOd6) 5 12.66 (bs, IH, NH), 10.37 (s, IH, NH), 9.79 (s, IH, NH), 7.71 (bs, 3H; Ar-H), 7.51 (d, J = 8.4 Hz, IH, Ar-H), 6.07-6.01 (bs, IH, Ar-H), 3.70 (bs, 4H, 2CH2), 2.33 (m, 4H, 2CH2), 2.20 (s, 3H, CH3), 1.85-1.78 (m, IH, CH), 1.84-1.82 (m, 4H, Ar-H); ESI-MS: calculated for (C25H27N9OS2) 517, found 518 [M+H]+. HPLC: retention time: 17.10 min. purity: 100%.<\/p>\n

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[334,131],"tags":[126],"class_list":["post-3717","post","type-post","status-publish","format-standard","hentry","category-96799-02-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 5-(Furan-2-yl)-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Product Details of 96799-02-9\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3717\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New learning discoveries about 5-(Furan-2-yl)-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New learning discoveries about 5-(Furan-2-yl)-1H-pyrazol-3-amine","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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