{"id":3696,"date":"2021-04-28T07:49:48","date_gmt":"2021-04-27T23:49:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3696"},"modified":"2021-04-28T07:49:48","modified_gmt":"2021-04-27T23:49:48","slug":"analyzing-the-synthesis-route-of-1h-pyrazol-1-ylmethanol-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3696","title":{"rendered":"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7<\/a><\/p>\n

Cystamine dihydrochloride (1.90 g, 8.43 mmol), N-hydroxymethylpyrazole(3.32 g, 33.9 mmol) and triethylamine (1.76 g,17.5 mmol) dissolved in dichloromethane (50 mL) were stirredfor 24 h at RT. The reaction mixture was extracted with water(30 mL) three times, after which the organic layer was dried overMgSO4 and the solvent was evaporated. This yielded L3 as a colorlessoil (3.96 g, 8.38 mmol, 99%), which was used without furtherpurification. 1H NMR (300 MHz, CD3CN, RT): d 2.65 (t, J = 7 Hz,4H, S-CH2), 2.94 (t, J = 7 Hz, 4H, S-CH2-CH2), 5.07 (s, 8H, N-CH2-Pz), 6.27 (t, J = 2 Hz, 4H, N-CH-CH), 7.47 (d, J = 1 Hz, 4H, N-CH),7.63 (d, J = 2 Hz, N-CH). 13C NMR (75 MHz, CD3CN, RT): d 37.1 (SCH2),50.2 (S-CH2-CH2), 68.9 (N-CH2-Pz), 106.6 (N-CH-CH), 130.8(N-CH), 140.1 (N-CH). ESI-MS found (calculated) for [M+Na]+ m\/z495.0 (495.2); [MC3+Na]+ m\/z 459.0 (459.2); [M2 C3+Na]+ m\/z422.9 (423.2); [M3 C3+Na]+ m\/z 387.0 (387.2); [M4 C3+Na]+m\/z 350.9 (351.2). IR (neat, cm1): 3110w, 2941w, 1513m,1393m, 1251m, 1121m, 1084s, 1046s, 962m, 743vs, 653m, 614s.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[185,131],"tags":[145],"class_list":["post-3696","post","type-post","status-publish","format-standard","hentry","category-1120-82-7","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nAnalyzing the synthesis route of (1H-Pyrazol-1-yl)methanol<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3696\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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