{"id":3695,"date":"2021-04-28T07:49:48","date_gmt":"2021-04-27T23:49:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3695"},"modified":"2021-04-28T07:49:48","modified_gmt":"2021-04-27T23:49:48","slug":"introduction-of-a-new-synthetic-route-about-1-methyl-1h-pyrazol-4-ylmethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3695","title":{"rendered":"Introduction of a new synthetic route about (1-Methyl-1H-pyrazol-4-yl)methanol"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H8N2O<\/a><\/p>\n

To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2 -amine (Intermediate E, 50 mg, O. l9mmol) and 1 -methyl -lH-pyrazol -4 -yl -methanol (207mg, l.85mmol) was added potassium 2-methylpropane-2-olate (1M in THF, l.85mL, l.85mmol) and the mixture was stirred for 30min. The mixture was transferred to a silica gel samplet which was subsequently loaded on to a Biotage Snap column. The residue was purified by column chromatography (Si02, hexane\/ethyl acetate). Combined fractions were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5mL) and water (lOmL), frozen and lyophilized to yield 3-(3-((6-((l-methyl-lH-pyrazol-4- yl)methoxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (8.5mg, 0.023mmol, 13%) as a white solid. MS: 363.2 [M+H]+.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[399,131],"tags":[126],"class_list":["post-3695","post","type-post","status-publish","format-standard","hentry","category-112029-98-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about (1-Methyl-1H-pyrazol-4-yl)methanol<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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