{"id":3681,"date":"2021-04-27T07:53:50","date_gmt":"2021-04-26T23:53:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3681"},"modified":"2021-04-27T07:53:50","modified_gmt":"2021-04-26T23:53:50","slug":"analyzing-the-synthesis-route-of-1h-pyrazol-1-ylmethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3681","title":{"rendered":"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol"},"content":{"rendered":"

Electric Literature of 1120-82-7<\/a>, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

General procedure: A solution of primary diamine (one equiv.) in acetonitrile(20 mL), was slowly added to a solution of 2a or 2b (fourequiv.) in 60 mL of acetonitrile. The reaction mixture was stirred under refluxed for 6h then dried over MgSO4. The solvent was removed under reduced pressure. The solid was dried using a Schlenk line. Transparent oil, yield = 65.69 % .IR ( (cm-1)): 3200 -2858 (CH); 1514 (C=N); 1440 (C=C); 1280 (C-N aromatic);1143 (C-N aliphatic). 1H NMR (300 MHz, CDCl3) (ppm):7.49 – 7 .36 (m, 8H, pz(5) \/pz(3)), 6.19 (t, 4H, pz, J = 3 Hz),4.85 (d, 8H, N-CH2-N, J = 3 Hz), 2.50 (t, 4H, N-CH2-CH2 ofamine, J = 3 Hz),1.57 – 1.51 (m, 2H, N-CH2-CH2 of amine).13C NMR (75 MHz, CDCl3, ppm): 139.59 (C(3)pz), 129.57(C(5)pz), 105.91(pz), 67.69(N-CH2-N), 48.85 (N-CH2-CH2 ofamine), 22.96 (N-CH2-CH2 of amine). MS [M+] (m\/z): calculated394,48, found 420,12 ([M++ Na+3]).<\/p>\n

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[185,131],"tags":[145],"class_list":["post-3681","post","type-post","status-publish","format-standard","hentry","category-1120-82-7","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nAnalyzing the synthesis route of (1H-Pyrazol-1-yl)methanol<\/title>\n<meta name=\"description\" content=\"Electric Literature of 1120-82-7, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 1120-82-7, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-26T23:53:50+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681\",\"name\":\"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-26T23:53:50+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 1120-82-7, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3681#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyzing the synthesis route of (1H-Pyrazol-1-yl)methanol\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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