{"id":3668,"date":"2021-04-27T07:53:05","date_gmt":"2021-04-26T23:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3668"},"modified":"2021-04-27T07:53:05","modified_gmt":"2021-04-26T23:53:05","slug":"simple-exploration-of-135-trimethyl-1h-pyrazole-4-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3668","title":{"rendered":"Simple exploration of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 2644-93-1<\/a><\/p>\n

(n-BuLi (1.02 mL, 2.5 M in hexane, 2.55 mmol) was added drop-wise to a -70 C. solution consisting of 3-(benzyloxy)-6-bromo-4-chloro-2-methoxy-8-methylquinoline (1.0 g, 2.5 mmol, Intermediate 89: step f) and THF (50 mL). The resultant reaction mixture was stirred at -70 C. for 20 minutes and then treated with a solution of 1,3,5-trimethyl-1H-pyrazole-4-carbaldehyde (352 mg, 2.55 mmol) and THF (15 mL) at -70 C. The resulting mixture was stirred at room temperature for 20 minutes before quenching with saturated aqueous NH4Cl (20 mL) and extracting with dichloromethane:methanol (5:1, 50 mL*10). The combined organic extracts were dried over Na2SO4, filtered and concentrated to dryness under reduced pressure to give the crude product, which was purified by FCC (silica gel, eluent: petroleum ether:ethyl acetate=5:1 to 1:1) to afford the title compound.<\/p>\n

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[391,131],"tags":[126],"class_list":["post-3668","post","type-post","status-publish","format-standard","hentry","category-2644-93-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 2644-93-1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3668\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde\" \/>\n<meta property=\"og:description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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