{"id":3667,"date":"2021-04-27T07:53:05","date_gmt":"2021-04-26T23:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3667"},"modified":"2021-04-27T07:53:05","modified_gmt":"2021-04-26T23:53:05","slug":"analyzing-the-synthesis-route-of-5-furan-2-yl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3667","title":{"rendered":"Analyzing the synthesis route of 5-(Furan-2-yl)-1H-pyrazol-3-amine"},"content":{"rendered":"

Related Products of 96799-02-9<\/a>, The chemical industry reduces the impact on the environment during synthesis 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.<\/p>\n

3- Ethynylaniline (146 mg, 1.25 mmol) and DIPEA (0. 22 mL, 1.25 mmol) were added to a solution of cyanuric chloride (230 mg, 1.25 mmol) in THF (16 mL) at 0 0C. The reaction mixture was stirred at 0 C to room temperature for 2 hours. 3-amino-5-(2-furyl) pyrazole (187 mg, 1.25 mmol) and DIPEA (0.22 mL, 1.25 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1 -methylpiperazine (0.28 mL, 2.50 mmol) and DIPEA (0.44 mL, 2.50 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 0C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column and eluted with 0- 5 % MeOH\/DCM which afforded compound 36 as light brown solid (130 mg, 24%). 1H NMR (400 MHz, DMSO-d6) delta 12.75 (bs, IH, NH), 10.19-9.44 (m, 2H, NH), 7.83- 6.06 (m, 8H, Ar- H), 4.14-4.04 (m, IH, CH), 3.77 (s, 4H, 2CH2), 2.37 (s, 4H, 2CH2), 2.22 (s, 3H, CH3); ESI- MS: calculated for (C23H23N9O) 441 , found 442 [M+H]+. HPLC: retention time: 15.31 min. purity: 95%.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Furan-2-yl)-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Furan-2-yl)-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[334,131],"tags":[126],"class_list":["post-3667","post","type-post","status-publish","format-standard","hentry","category-96799-02-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 5-(Furan-2-yl)-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Related Products of 96799-02-9, The chemical industry reduces the impact on the environment during synthesis 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 5-(Furan-2-yl)-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Related Products of 96799-02-9, The chemical industry reduces the impact on the environment during synthesis 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-26T23:53:05+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667\",\"name\":\"Analyzing the synthesis route of 5-(Furan-2-yl)-1H-pyrazol-3-amine\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-26T23:53:05+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 96799-02-9, The chemical industry reduces the impact on the environment during synthesis 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3667#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyzing the synthesis route of 5-(Furan-2-yl)-1H-pyrazol-3-amine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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