{"id":3662,"date":"2021-04-27T07:53:05","date_gmt":"2021-04-26T23:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3662"},"modified":"2021-04-27T07:53:05","modified_gmt":"2021-04-26T23:53:05","slug":"extended-knowledge-of-3-trifluoromethyl-1h-pyrazole-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3662","title":{"rendered":"Extended knowledge of 3-(Trifluoromethyl)-1H-pyrazole"},"content":{"rendered":"

Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C4H3F3N2<\/a><\/p>\n

[00554] Intermediate 55a: ethyl 2-[3-(trifluoromethyl)pyrazol-1-yI]acetate[00555] A solution of 3-(trifluoromethyl)-1 H-pyrazole (75mg, 0.SSmmol) and potassium carbonate (228mg, 1 .6Smmol) were left to stir in MeCN (2mL) for 30 minutes before the addition of ethyl bromoacetate (0.O9mL, 0.83mmol). The reaction mixture was then heated to 60 \u00b0C and left to stir for 2 hours. The reaction mixture was quenched by the addition of water (2OmL) and extractedusing EtOAc (3 x 2OmL). The organic layers were combined, dried over Na2504, filtered andconcentrated in vacuo to give ethyl 2-[3-(trifluoromethyl)pyrazol-1-yl]acetate (1 20mg, 0.SSmmol,100percent yield) as a yellow oil which was used in the next step without further purification.1H NMR (CDCI3,400MHz) O\/ppm: 7.55 (1H, dd, J= 2.3Hz, 0.9Hz), 6.59 (1H, d, J= 2.2Hz), 4.96 (2H,5), 4.25 (2H, q, J= 7.1Hz), 1.29 (3H, t, J= 7.1Hz).MS Method 2: RT: 1.58 mi m\/z 223.1 [M+H]<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20154-03-4, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20154-03-4, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[126],"class_list":["post-3662","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 3-(Trifluoromethyl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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