{"id":3660,"date":"2021-04-27T07:53:05","date_gmt":"2021-04-26T23:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3660"},"modified":"2021-04-27T07:53:05","modified_gmt":"2021-04-26T23:53:05","slug":"analyzing-the-synthesis-route-of-1h-pyrazole-4-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3660","title":{"rendered":"Analyzing the synthesis route of 1H-Pyrazole-4-carboxylic acid"},"content":{"rendered":"

Related Products of 37718-11-9<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37718-11-9, name is 1H-Pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

To the mixture of 4-(4-methylpiperazin-1-yl)-2- (piperidin-1-yl)aniline (0.5 g, 1.82 mmol), 4-cyanofuran-2-carboxylic acid (0.3 g, 2.18 mmol), HATU (0.83 g, 2.18 mmol), in DMF (10 mL) was added DIPEA (0.63 mL, 3.64 mmol). The reaction mixture was stirred at room temperature overnight and then partitioned between EtOAc and brine. The organic layer was separated, dried over anhydrous MgSO4, filtered, and concentrated under a vacuum. The resulting residue was purified by silica gel column chromatography (CH2Cl2: MeOH = 9:1) to give 4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2- carboxamide as a pale yellow solid (0.62 g, 86.1% yield).1H NMR (500 MHz, CDCl3) d 9.41 (s, 1H), 8.31 (d, J = 8.7 Hz, 1H), 8.03 (s, 1H), 7.33 (s, 1H), 6.78 (s, 1H), 6.72 (d, J = 8.8 Hz, 1H), 3.19 (s, 4H), 2.83 (s, 4H), 2.59 (s, 4H), 2.36 (s, 3H), 1.76 (s, 4H), 1.63 (s, 2H).<\/p>\n

The synthetic route of 1H-Pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1H-Pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[400,131],"tags":[126],"class_list":["post-3660","post","type-post","status-publish","format-standard","hentry","category-37718-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 1H-Pyrazole-4-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Related Products of 37718-11-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37718-11-9, name is 1H-Pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3660\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 1H-Pyrazole-4-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Related Products of 37718-11-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37718-11-9, name is 1H-Pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3660\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-26T23:53:05+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3660\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3660\",\"name\":\"Analyzing the synthesis route of 1H-Pyrazole-4-carboxylic acid\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-26T23:53:05+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 37718-11-9, In the next few decades, the world population will flourish. 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