{"id":3611,"date":"2021-04-25T06:34:44","date_gmt":"2021-04-24T22:34:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3611"},"modified":"2021-04-25T06:34:44","modified_gmt":"2021-04-24T22:34:44","slug":"application-of-5-cyclopropyl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3611","title":{"rendered":"Application of 5-Cyclopropyl-1H-pyrazol-3-amine"},"content":{"rendered":"

Related Products of 175137-46-9<\/a>,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a cold solution of 4,6-dichloropyrimidine-5-carbonitrile (500 mg, 2.87 mmol) in THF (10 mL) was added N,N-diisopropylethylamine (1.00 ml g, 5.75 mmol), followed by a solution of 3-cylopropyl-1-H-pyrazole amine (354 mg, 2.87 mmol) at 0 C. The resulting mixture was stirred at 0 C. for 2 hours. TLC was checked and the reaction was completed. After cooled to room temperature, half-saturated ammonium chloride in water (80 mL) was added and the mixture was stirred at room temperature for 15 min. The resulting solids were collected by filtration, washed by water to afford product compound 2 as yellow solids. (644 mg, 86% yield). 1H NMR (400 MHz, DMSO-d6) delta 12.42 (br, 1H), 10.35 (br, 1H), 8.55 (s, 1H), 6.12 (s, 1H), 1.89 (m, 1H), 0.92 (m, 2H), 0.67 (m, 2H); ESI-MS: calcd for (C11H9ClN6) 260, found 261 (MH+).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[189,131],"tags":[126],"class_list":["post-3611","post","type-post","status-publish","format-standard","hentry","category-175137-46-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 5-Cyclopropyl-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Related Products of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 5-Cyclopropyl-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Related Products of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-24T22:34:44+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611\",\"name\":\"Application of 5-Cyclopropyl-1H-pyrazol-3-amine\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-24T22:34:44+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3611#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Application of 5-Cyclopropyl-1H-pyrazol-3-amine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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