{"id":3610,"date":"2021-04-25T06:34:44","date_gmt":"2021-04-24T22:34:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3610"},"modified":"2021-04-25T06:34:44","modified_gmt":"2021-04-24T22:34:44","slug":"the-important-role-of-methyl-5-nitro-1h-pyrazole-3-carboxylate-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3610","title":{"rendered":"The important role of Methyl 5-nitro-1H-pyrazole-3-carboxylate"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181585-93-3 as follows. name: Methyl 5-nitro-1H-pyrazole-3-carboxylate<\/a><\/p>\n

[0567] To a solution of 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (200 mg, 1.17 mmol) in dry THF (10 mL) was added LiBH4 (2.34 mL, 2 M in THF) at 0 C, and the resulting mixture was allowed to warm to room temperature and stirred overnight. The reaction was monitored by TLC. Then the reaction was quenched with H20 (10 mL), and the mixture was extracted with EtOAc (20 mL x3). The combined organic layers were concentrated in vacuum to afford (5-nitro-lH-pyrazol-3-yl)-methanol (154 mg, yield: 92%) as a white solid. [0568] 1H MR (400 MHz, DMSO-6): delta = 13.89 (brs, 1H), 6.86 (d, J = 1.6 Hz, 1H), 5.57 (brs, 1H), 4.53 (s, 2H).<\/p>\n

According to the analysis of related databases, 181585-93-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 181585-93-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[425,131],"tags":[126],"class_list":["post-3610","post","type-post","status-publish","format-standard","hentry","category-181585-93-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of Methyl 5-nitro-1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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