{"id":3600,"date":"2021-04-25T06:33:59","date_gmt":"2021-04-24T22:33:59","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3600"},"modified":"2021-04-25T06:33:59","modified_gmt":"2021-04-24T22:33:59","slug":"a-new-synthetic-route-of-tert-butyl-46-dihydropyrrolo34-cpyrazole-52h-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3600","title":{"rendered":"A new synthetic route of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1280210-79-8, HPLC of Formula: C10H15N3O2<\/a><\/p>\n

under nitrogen protection, Intermediate 2(1000 mg, 4.78mmol) is dissolved in N, N – dimethyl formamide(15ml), lowering the temperature to -15 C, sodium bis(trimethylsilyl)amide (4.78 ml, 2 mol\/L, 9.56mmol), was added stirring 30 minutes, will S – tetrahydrofuran -3 – sulfonyl chloride (1.39g, 8.13mmol) is added in the reaction solution, to maintain this temperature reaction is 16 hours. The end of the reaction, raising the temperature to 0 C, adding water to the reaction solution (20 ml) quenching the reaction, ethyl acetate (20mL \u00d7 2) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated, re-dissolved in tetrahydrofuran (20 ml) in, cooling to -10 C to 0 C. Adding 3rd butanol potassium (85 mg, 0.76mmol), this temperature is kept under 24 hours reaction. The end of the reaction, by adding saturated ammonium chloride solution (10 ml), water (10 ml), ethyl acetate (20mL \u00d7 3) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Silica gel column chromatography separation and purification of the residue (petroleum ether\/ethyl acetate (v\/v)=5:1), to obtain white solid5a(810 mg, 62.3% yield).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[222,131],"tags":[127],"class_list":["post-3600","post","type-post","status-publish","format-standard","hentry","category-1280210-79-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nA new synthetic route of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1280210-79-8, HPLC of Formula: C10H15N3O2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3600\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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