{"id":3567,"date":"2021-04-23T06:34:19","date_gmt":"2021-04-22T22:34:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3567"},"modified":"2021-04-23T06:34:19","modified_gmt":"2021-04-22T22:34:19","slug":"a-new-synthetic-route-of-135-trimethyl-1h-pyrazole-4-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3567","title":{"rendered":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid"},"content":{"rendered":"

Related Products of 1125-29-7<\/a>, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

A suspension of triphenylphosphine (59.3 mg, 0.226 mmol) and 1,3, [5-TRIMETHYL-LH-] pyrazole-4-carboxylic acid (SALOR) (26.8 mg, 0.174 mmol) in dichloromethane was cooled to [0 oC AND N-CHLOROSUCCINIMIDE] added. The mixture was stirred at [0 oC] for 0.5 h then ambient temperature for an additional 0.5 h. [3-CYCLOPROPYLMETHYL-8- [4-] (ETHYL-AMINO)-BENZYL]-1-(2-FLUOROBENZYL)-3,] 7-dihydro-purine-2,6-dione (93.4 mg, 0.209 mmol) was added followed by triethylamine (30.2 mg, 0.226 mmol) and 4- dimethylaminopyridine (a few crystals). The reaction was left to stir at ambient temperature overnight before washing with 1M aqueous hydrochloric acid, saturated aqueous sodium bicarbonate, drying the organic extract (sodium sulfate) and concentrating in vacuo. Purification by chromatography using silica eluted with 5: 9 methanol\/dichloromethane gave the product as a colorless solid (83.5 mg, 69%).<\/p>\n

Statistics shows that 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 1125-29-7.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 1125-29-7.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[143,131],"tags":[126],"class_list":["post-3567","post","type-post","status-publish","format-standard","hentry","category-1125-29-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-22T22:34:19+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567\",\"name\":\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-22T22:34:19+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=3567#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid","description":"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567","og_locale":"en_US","og_type":"article","og_title":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid","og_description":"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-04-22T22:34:19+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567","name":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-04-22T22:34:19+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.","breadcrumb":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.pyrazoles-derivatives.com\/?p=3567"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=3567#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"A new synthetic route of 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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