{"id":3552,"date":"2021-04-21T09:28:54","date_gmt":"2021-04-21T01:28:54","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3552"},"modified":"2021-04-21T09:28:54","modified_gmt":"2021-04-21T01:28:54","slug":"some-scientific-research-about-methyl-3-methyl-1h-pyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3552","title":{"rendered":"Some scientific research about Methyl 3-methyl-1H-pyrazole-4-carboxylate"},"content":{"rendered":"

Synthetic Route of 23170-45-8<\/a>,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

General procedure: Compound (3a-e) (1.2mmol), CuI (19.1mg, 0.1mmol), trans-N, N?-dimethyl-1, 2-cyclohexane-diamine (29mg, 0.2mmol), K2CO3 (0.29g, 2.1mmol) and DMF (3mL) were added to a tube filled with argon. The mixture was stirred at 110C for 24h, diluted with H2O (20mL), and extracted with EtOAc (15mL\u00d72). The combined organic phases were washed with H2O (20mL\u00d72) and brine (30mL), dried over MgSO4 and concentrated in a vacuum. The residue was purified by flash column chromatography (12-25% EtOAc in petroleum ether).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-methyl-1H-pyrazole-4-carboxylate, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-methyl-1H-pyrazole-4-carboxylate, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[397,131],"tags":[126],"class_list":["post-3552","post","type-post","status-publish","format-standard","hentry","category-23170-45-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about Methyl 3-methyl-1H-pyrazole-4-carboxylate<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some scientific research about Methyl 3-methyl-1H-pyrazole-4-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-21T01:28:54+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552\",\"name\":\"Some scientific research about Methyl 3-methyl-1H-pyrazole-4-carboxylate\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-21T01:28:54+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3552#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some scientific research about Methyl 3-methyl-1H-pyrazole-4-carboxylate\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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