{"id":3536,"date":"2021-04-21T09:28:12","date_gmt":"2021-04-21T01:28:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3536"},"modified":"2021-04-21T09:28:12","modified_gmt":"2021-04-21T01:28:12","slug":"introduction-of-a-new-synthetic-route-about-1-methyl-1h-pyrazol-5-amine-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3536","title":{"rendered":"Introduction of a new synthetic route about 1-Methyl-1H-pyrazol-5-amine"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Methyl-1H-pyrazol-5-amine<\/a><\/p>\n

(3 S)-7-(2-Chloro-5-methylpyrimidin-4-yl)-3-methyl-2-((2-methylpyrimidin-4-yl)methyl)- 3 ,4-dihydropyrrolo [1 ,2-a]pyrazin- 1 (2H)-one (122 mg, 0.32 mmol), i-methyl-i H-pyrazol5-amine (37.1 mg, 0.38 mmol) and cesium carbonate (228 mg, 0.70 mmol) were suspended in tert-butanol (2 mL) and de-gassed with nitrogen for 5 minutes, then BrettPhos 3rd generation pre-catalyst (14.44 mg, 0.02 mmol) was added. The reaction was heated to100 \u00b0C in the microwave for 1 hour, then allowed to cool to ambient temperature, diluted with DCM (30m1), washed with brine (30m1), separated, dried (MgSO4) and evaporated to afford crude product, which was purified by preparative HPLC (Waters XBridge Prep Ci 8 OBD column, Sji silica, 30 mm diameter, 100 mm length), using decreasingly polar mixtures of water (containing 1percent NH3) and MeCN as eluents. Fractions containing thedesired compound were evaporated to dryness to afford (3S)-3-methyl-7-(5-methyl-2-((i- methyl-i H-pyrazol-5 -yl)amino)pyrimidin-4-yl)-2-((2-methylpyrimidin-4-yl)methyl)-3 ,4- dihydropyrrolo[i,2-a]pyrazin-i(2H)-one (67.2 mg, 47.5 percent) as a pale yellow gum. 1H NMR (500 MHz, DMSO, 30 \u00b0C) 1.20 (3H, d), 2.34 (3H, s), 2.62 (3H, s), 3.70 (3H, s), 3.97 – 4.05 (iH, m), 4.24 (iH, dd), 4.34 (iH, d), 4.47 (iH, dd), 5.10 (iH, d), 6.27 (iH, d), 7.27 (iH,d), 7.29 (iH, d), 7.34 (iH, d), 7.69 (iH, d), 8.25 (iH, s), 8.63 (iH, d), 9.09 (iH, s). mlz:ES+ [M+H]+ 444.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1192-21-8.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1192-21-8.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,131],"tags":[145],"class_list":["post-3536","post","type-post","status-publish","format-standard","hentry","category-1192-21-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about 1-Methyl-1H-pyrazol-5-amine<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. 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