{"id":3533,"date":"2021-04-21T09:28:12","date_gmt":"2021-04-21T01:28:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3533"},"modified":"2021-04-21T09:28:12","modified_gmt":"2021-04-21T01:28:12","slug":"share-a-compound-4-bromo-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3533","title":{"rendered":"Share a compound : 4-Bromo-1H-pyrazol-3-amine"},"content":{"rendered":"

Some common heterocyclic compound, 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, molecular formula is C3H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Bromo-1H-pyrazol-3-amine<\/a><\/p>\n

General procedure: A soln. of amine BB-34 (1 eq) and aldehyde or ketone BB-12 (1.05 to 1.1 eq) in MeOH (2 to 4 mL\/mmol) was stirred for 1 h at RT. NaBI-U (1.6 to 2 eq) was added portionwise at 0C and the rxn mixture was stirred at a given temperature for a given time (see Table 52). It was quenched with H2O at 0C and extracted with EtOAc. The combined org. phases were washed with brine, dried over MgSCh and concentrated in vacuo. When necessary, the crude was purified by CC using EtOAc\/MeOH<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16461-94-2, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16461-94-2, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[188,131],"tags":[126],"class_list":["post-3533","post","type-post","status-publish","format-standard","hentry","category-16461-94-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 4-Bromo-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, molecular formula is C3H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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