{"id":3521,"date":"2021-04-20T08:50:40","date_gmt":"2021-04-20T00:50:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3521"},"modified":"2021-04-20T08:50:40","modified_gmt":"2021-04-20T00:50:40","slug":"brief-introduction-of-ethyl-5-amino-1h-pyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3521","title":{"rendered":"Brief introduction of Ethyl 5-amino-1H-pyrazole-4-carboxylate"},"content":{"rendered":"

Electric Literature of 1260243-04-6<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1260243-04-6 name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate (20.0 g, 129 mmol), (E)-ethyl 3-ethoxyacrylate (22.4 mL, 155 mmol) and cesium carbonate (63.0 g, 193 mmol) in DMF (322 mL) was stirred at 110 C. overnight. After being cooled to 0 C., the reaction mixture was acidified with 2 N aq. HCl. A precipitated solid was collected by filtration and washed with water and EtOAc to afford ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (24.7 g, 92%) as a pale yellow solid. 1H-NMR (DMSO-d6, Varian, 400 MHz): delta 1.27 (3H, t, J=7.2 Hz), 4.80 (2H, q, J=6.8 Hz), 6.16 (1H, d, J=8.0 Hz), 8.14 (1H, s), 8.58 (1H, d, J=8.0 Hz), 11.7 (1H, br. s).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-amino-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-amino-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[213,131],"tags":[126],"class_list":["post-3521","post","type-post","status-publish","format-standard","hentry","category-1260243-04-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of Ethyl 5-amino-1H-pyrazole-4-carboxylate<\/title>\n<meta name=\"description\" content=\"Electric Literature of 1260243-04-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1260243-04-6 name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3521\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brief introduction of Ethyl 5-amino-1H-pyrazole-4-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 1260243-04-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1260243-04-6 name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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