{"id":3518,"date":"2021-04-20T08:50:40","date_gmt":"2021-04-20T00:50:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3518"},"modified":"2021-04-20T08:50:40","modified_gmt":"2021-04-20T00:50:40","slug":"sources-of-common-compounds-1-methyl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3518","title":{"rendered":"Sources of common compounds: 1-Methyl-1H-pyrazol-3-amine"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-31-0 as follows. category: pyrazoles-derivatives<\/a><\/p>\n

Example Q (0350) 4-(((4-(4-Fluorophenyl)pyridin-2-yl)(1 -methyl-1 H-pyrazol-3-yl)amino)methyl)-N- hy (0351) (0352) Q 2- Chloro-4-(4-fluorophenyl)pyridine (1 ) (1.0g, 4.8mmol), 1 -methyl- 1 H-pyrazol-3- amine (2) (470mg, 4.8mmol), Xantphos (0.28g, 0.48mmol) and Cs2C03 (2.35g, 7.24mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10min. Pd2(dba)3 (0.22g, 0.24mmol) was then added and the resulting reaction mixture was heated at 90\u00a1\u00e3C for 30h. It was then poured onto demineralised water (200ml_) and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc\/Hexane (1 : 1) to provide 4-(4-fluorophenyl)-N-(1-methyl- 1 H-pyrazol-3-yl)pyridin-2-amine (3) as a yellow solid (1.0g, 71 percent). (0353) LCMS (ES): Found 269.1 [M+H]+.<\/p>\n

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-3518","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSources of common compounds: 1-Methyl-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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