{"id":3510,"date":"2021-04-20T08:49:40","date_gmt":"2021-04-20T00:49:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3510"},"modified":"2021-04-20T08:49:40","modified_gmt":"2021-04-20T00:49:40","slug":"extracurricular-laboratory-synthetic-route-of-allyl-35-diamino-1h-pyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3510","title":{"rendered":"Extracurricular laboratory: Synthetic route of Allyl 3,5-diamino-1H-pyrazole-4-carboxylate"},"content":{"rendered":"

These common heterocyclic compound, 1613191-73-3, name is Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H10N4O2<\/a><\/p>\n

Preparation 2a: lH-benzo[d] [l,2,3]triazol-l-yl 2-amino-6-fluoropyrazolo[l,5- a] pyrimidine-3-carboxylate 6a Step 1: allyl 2-amino-6-fluoro-pyrazolo [ 1 ,5-a] pyrimidine-3-carboxylate 4a [00244] To a suspension of allyl 3,5-diamino-lH-pyrazole-4-carboxylate 3 (42.72 g, 234.5 mmol) in DMSO (270.8 mL) \/ Water (270.8 mL), was added p-TsOH hydrate (46.72 g, 245.6 mmol) and 3-(diisopropylamino)-2-fluoro-prop-2-enal (described in Tetrahedron Letters, 33(3), 357-60; 1992) (38.69 g, 223.3 mmol). The reaction mixture was heated to 100C for 3h during which time a solid slowly precipitated out of solution. The orange suspension was allowed to cool down to RT overnight. The solid was filtered, washed with water and dried under vacuum to give allyl 2-amino-6-fluoro-pyrazolo[l,5-a]pyrimidine-3-carboxylate 4a as a sand solid (45.05 g, 85% yield).<\/p>\n

The synthetic route of Allyl 3,5-diamino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Allyl 3,5-diamino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[251,131],"tags":[126],"class_list":["post-3510","post","type-post","status-publish","format-standard","hentry","category-1613191-73-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of Allyl 3,5-diamino-1H-pyrazole-4-carboxylate<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 1613191-73-3, name is Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H10N4O2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3510\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of Allyl 3,5-diamino-1H-pyrazole-4-carboxylate\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 1613191-73-3, name is Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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