{"id":3507,"date":"2021-04-20T08:49:40","date_gmt":"2021-04-20T00:49:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3507"},"modified":"2021-04-20T08:49:40","modified_gmt":"2021-04-20T00:49:40","slug":"share-a-compound-5-isopropoxy-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3507","title":{"rendered":"Share a compound : 5-Isopropoxy-1H-pyrazol-3-amine"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 5-Isopropoxy-1H-pyrazol-3-amine<\/a><\/p>\n

Example 68; N’-(5-isopropoxy-1H-pyrazol-3-yl)-6-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrimidine-2,4-diamine (also known as 6-methyl-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-N’-(5-propan-2-yloxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine)A mixture of 4-chloro-6-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrimidin-2-amine (also known as 4-chloro-6-methyl-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidin-2-amine; 0.20 g, 0.84 mmol) and 5-isopropoxy-1H-pyrazol-3-amine (0.178 g, 1.26 mmol) in anhydrous 1-methylpyrrolidinone (2 mL) and 4M hydrogen chloride solution in dioxane (0.42 mL) was heated at 110 C. for 4 hours. The mixture was left to stand at room temperature overnight and was then diluted with saturated sodium bicarbonate solution and extracted with ethyl acetate (\u00a1\u00c12). The organic extracts were washed with brine, dried over magnesium sulfate, filtered and then evaporated to leave an orange oil. The oil was purified by chromatography on silica eluting with a mixture of 2-4% methanol in dichloromethane. Fractions containing product were combined and then evaporated to leave a solid which was triturated with diethyl ether to leave example 68 in table 4 (0.039 g, 12% yield).1H NMR (500 MHz, DMSO at 373K): 1.28 (d, 6H), 2.15 (s, 3H), 2.19 (s, 3H), 4.58 (d, 2H), 4.64 (bs, 1H), 5.25 (bs, 1H), 5.41 (bs, 1H), 6.12 (s, 1H), 7.2 (bs, 1H), 9.33 (bs, 1H), 11.39 (bs, 1H).MS: m\/z 344 (MH+).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346,131],"tags":[126],"class_list":["post-3507","post","type-post","status-publish","format-standard","hentry","category-121507-34-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 5-Isopropoxy-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 5-Isopropoxy-1H-pyrazol-3-amine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3507\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 5-Isopropoxy-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 5-Isopropoxy-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3507\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-20T00:49:40+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3507\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3507\",\"name\":\"Share a compound : 5-Isopropoxy-1H-pyrazol-3-amine\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-20T00:49:40+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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