{"id":3499,"date":"2021-04-20T08:49:40","date_gmt":"2021-04-20T00:49:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3499"},"modified":"2021-04-20T08:49:40","modified_gmt":"2021-04-20T00:49:40","slug":"sources-of-common-compounds-3-ethyl-1-methyl-1h-pyrazole-5-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3499","title":{"rendered":"Sources of common compounds: 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 26308-42-9<\/a><\/p>\n

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one (0.100 g, 0.44 mmol) and 3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (0.074 g, 0.48 mmol), and pyridine (0.16 mL, 1.96 mmol) in acetonitrile (4 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.91 mL, 1.53 mmol). The sealed tube was heated to 50 C. for 5 days and the precipitation formed. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile\/water to give 3-ethyl-1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-5-carboxamide (0.044 g, 26%). 1H NMR (400 MHz, DMSO-d): delta 12.64 (bs, 1H), 10.19 (s, 1H), 7.76 (m, 1H), 7.69 (dd, 1H, J=8.4, 2.0 Hz), 7.54 (s, 1H), 7.22 (s, 3H), 6.91 (d, 1H, J=8.0 Hz), 4.07 (s, 3H), 2.93 (t, 2H, J=7.2 Hz), 2.59 (m, 2H), 1.19 (t, 3H, J=7.6 Hz). MS (ESI): Calcd. for C19H19N5O2S: 381, found 382 (M+1)+.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[130,131],"tags":[126],"class_list":["post-3499","post","type-post","status-publish","format-standard","hentry","category-26308-42-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 26308-42-9\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3499\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds: 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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