{"id":3488,"date":"2021-04-19T06:35:10","date_gmt":"2021-04-18T22:35:10","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3488"},"modified":"2021-04-19T06:35:10","modified_gmt":"2021-04-18T22:35:10","slug":"simple-exploration-of-4-nitro-1h-pyrazole-3-carboxylic-acid-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3488","title":{"rendered":"Simple exploration of 4-Nitro-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

Application of 5334-40-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-40-7 as follows.<\/p>\n

A solution of l-methanesulphonyl-piperidin-4-ylamine hydrochloride (2.4 g, 11.1 mmoles), 4-nitro-1H-pyrazole-3-carboxylic acid (1.8 g, 11.1 mmoles), EDC (2.6 g (13.5 mmoles), HOBt (1.8 g, 13.3 mmoles) and triethylamine (3.4 ml, 24.6 mmoles) in DMF (30 ml) was stirred at room temperature for 24 hours. The reaction mixture was partitioned between EtOAc and a saturated solution of sodium hydrogen carbonate. The organic portion was dried (MgSO4), filtered and evaporated in vacuo to give 4-nitro-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl- piperidin-4-yl)-amide as a pale orange solid (1.7g, 48percent).<\/p>\n

According to the analysis of related databases, 5334-40-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 5334-40-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[153,131],"tags":[126],"class_list":["post-3488","post","type-post","status-publish","format-standard","hentry","category-5334-40-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 4-Nitro-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Application of 5334-40-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-40-7 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3488\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of 4-Nitro-1H-pyrazole-3-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"Application of 5334-40-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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