{"id":3477,"date":"2021-04-19T06:34:14","date_gmt":"2021-04-18T22:34:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3477"},"modified":"2021-04-19T06:34:14","modified_gmt":"2021-04-18T22:34:14","slug":"the-important-role-of-2-1h-pyrazol-3-ylpyridine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3477","title":{"rendered":"The important role of 2-(1H-Pyrazol-3-yl)pyridine"},"content":{"rendered":"

Related Products of 75415-03-1<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75415-03-1 as follows.<\/p>\n

1st step: adding to the reaction kettle 2.1g2 – (1H-pyrazol-3-yl) pyridine and 3.7g2- bromopyridine [2 – (1H-pyrazol-3-yl) pyridine and 2-polybromide pyridine mole ratio of 1 : 1.6], in the reactor is placed into an oven after heating to 190 C, reaction 24h;2nd step: after the reaction is ended, take the solid using saturated Na2CO3solution cleaning, separating out the solid;3rd step: the separate the solid is dried fully then dissolved in chloroform, using silica gel as stationary phase, the volume of the petroleum ether and ethyl acetate ratio of 1:1 as the eluting agent mixed solution of dry-column, collecting product, evaporation and concentration, drying, the obtained yellow solid powder is the target product, nuclear product resonating chart as shown in Figure 1, the yield of 70.1%. The eluting agent is added before the dissolving solid petroleum ether for use out of the chloroform solution. he basic steps of the embodiment 1 the same, but in 1st step 2 – (1H-pyrazol-3-yl) pyridine and 2-bromo pyridine molar ratio of 1 : 1.5, the heating temperature is 180 C, the reaction time is 30h, saturation, solid in 2nd step NaHCO3solution cleaning, the obtained yield of 71.0%.<\/p>\n

According to the analysis of related databases, 75415-03-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 75415-03-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[225,131],"tags":[126],"class_list":["post-3477","post","type-post","status-publish","format-standard","hentry","category-75415-03-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 2-(1H-Pyrazol-3-yl)pyridine<\/title>\n<meta name=\"description\" content=\"Related Products of 75415-03-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75415-03-1 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3477\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 2-(1H-Pyrazol-3-yl)pyridine\" \/>\n<meta property=\"og:description\" content=\"Related Products of 75415-03-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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