{"id":3475,"date":"2021-04-19T06:34:14","date_gmt":"2021-04-18T22:34:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3475"},"modified":"2021-04-19T06:34:14","modified_gmt":"2021-04-18T22:34:14","slug":"the-important-role-of-methyl-5-hydroxy-1-methyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3475","title":{"rendered":"The important role of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate"},"content":{"rendered":"

Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O3<\/a><\/p>\n

Intermediate 17-65 (200 mg, 1.28 mmol) and POBr3 (500 mg, 1.74 mmol) are dissolved in MeCN (30 mL) and the resulting solution is heated in a sealed flask at 80 C for 3 h. The solution is cooled down and slowly poured into saturated NaHC03 solution (50 mL) and extracted with EtOAc. The combined extracts is washed with brine, dried over MgS04 and concentrated to afford intermediate 17-66 (200 mg).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[293,131],"tags":[126],"class_list":["post-3475","post","type-post","status-publish","format-standard","hentry","category-51985-95-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3475\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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