{"id":3457,"date":"2021-04-15T05:46:18","date_gmt":"2021-04-14T21:46:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3457"},"modified":"2021-04-15T05:46:18","modified_gmt":"2021-04-14T21:46:18","slug":"brief-introduction-of-1-phenylpyrazole-4-carboxaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3457","title":{"rendered":"Brief introduction of 1-Phenylpyrazole-4-carboxaldehyde"},"content":{"rendered":"

Reference of 54605-72-0<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54605-72-0, name is 1-Phenylpyrazole-4-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

Example 78 This example illustrates the preparation of 7-Methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid ((S)-1-cyclobutyl-pyrrolidin-2-ylmethyl)-(1-phenyl-1H-pyrazol-3-ylmethyl)-amide. Experimental conditions analogous to Example 1, from 0.16 g (0.81 mmol) of (S)-2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester, 70 mg (0.41 mmol) of 1-phenyl-1H-pyrazole-4-carbaldehyde, 4 mL dichloromethane, and 0.17 g (0.81 mmol) of sodium triacetoxyborohydride. (1-Phenyl-1H-pyrazol-3-ylmethyl)-pyrrolidin-2-ylmethyl-amine was treated with 566 muL (4.06 mmol) of triethylamine and 0.43 g (1.79 mmol) of 7-methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carbonyl chloride. The compound was deprotected using 3 mL of 10% TFA in dichloromethane. 7-Methoxy-2,2-dimethyl-benzo[1,3]-dioxolo-5-carboxylic acid (1-cyclobutyl-pyrrolidin-2-ylmethyl)-[1-(1-ethylidene-penta-2,4-dienyl)-1H-pyrazol-3-ylmethyl]-amide was alkylated using 98 mg (1.22 mmol) cyclobutanone and 0.25 g (1.22 mmol) of sodium triacetoxyborohydride. The compound was purified using reverse phase HPLC, mobile phase with a gradient 20-80% acetonitrile in 50 min, gave 50 mg of white solid as the trifluoroacetate. LC-MSD, m\/z for C30H36N4O4 [M+H]+: 517.7. 1H NMR (400 MHz, CDCl3): delta 1.7-2.4 (m, 17H), 2.9-3.1 (m, 1H), 3.6-3.8 (m, 2H), 3.9 (s, 3H), 3.9-4.0 (m, 2H), 4.6-4.8 (m, 2H), 6.6 (s, 1H), 6.7 (s, 1H), 7.3-7.4 (m, 1H), 7.4-7.5 (m, 2H), 7.5 (bs, 1H), 7.6-7.8 (m, 4H), 8.0 (s, 1H), 11.1 (bs, 1H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-Phenylpyrazole-4-carboxaldehyde. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-Phenylpyrazole-4-carboxaldehyde. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[132,131],"tags":[126],"class_list":["post-3457","post","type-post","status-publish","format-standard","hentry","category-54605-72-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of 1-Phenylpyrazole-4-carboxaldehyde<\/title>\n<meta name=\"description\" content=\"Reference of 54605-72-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54605-72-0, name is 1-Phenylpyrazole-4-carboxaldehyde, This compound has unique chemical properties. 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