{"id":3452,"date":"2021-04-15T05:46:18","date_gmt":"2021-04-14T21:46:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3452"},"modified":"2021-04-15T05:46:18","modified_gmt":"2021-04-14T21:46:18","slug":"introduction-of-a-new-synthetic-route-about-3-tert-butyl-1-methylpyrazole-5-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3452","title":{"rendered":"Introduction of a new synthetic route about 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 175277-11-9, name is 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid, A new synthetic method of this compound is introduced below., Safety of 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid<\/a><\/p>\n

11) 3-(tert-butyl)-N-(3-chloro-4-methylbenzyl)-1-methyl-1H-pyrazole-5-carboxamide To a solution of the Acid (257 mg, 1.41 mmol, 1.1 eq) in DMF (10 mL) was added an amine (200 mg, 1.29 mmol, 1.0 eq), DIEA (830 mg, 6.43 mmol, 5 eq) and HBTU (584 mg, 1.54 mmol, 1.2 eq) and the reaction mixture was stirred at rt for 12 h. The reaction mixture was then diluted with ethyl acetate (30 mL) and washed with 10% aqHCl (1*25 mL), sat NaHCO3 (1*25 mL) and water (4*25 mL). Organic layer was collected, dried (MgSO4) and evaporated to give a crude product, which was purified by column chromatography (10% to 50% EtOAc in Hexane) to give the amide as a colorless solid in 66% (165 mg, >95% purity). Mass Spectrum (LCMS, ESI Pos.) Calcd. For C17H23ClN3O: 320.0 (M+H), Found 320.0.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[405,131],"tags":[126],"class_list":["post-3452","post","type-post","status-publish","format-standard","hentry","category-175277-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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