{"id":3451,"date":"2021-04-15T05:46:18","date_gmt":"2021-04-14T21:46:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3451"},"modified":"2021-04-15T05:46:18","modified_gmt":"2021-04-14T21:46:18","slug":"introduction-of-a-new-synthetic-route-about-1-methyl-1h-pyrazole-5-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3451","title":{"rendered":"Introduction of a new synthetic route about 1-Methyl-1H-pyrazole-5-carbaldehyde"},"content":{"rendered":"

27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-Methyl-1H-pyrazole-5-carbaldehyde<\/a><\/p>\n

General procedure: A mixture of the corresponding secondary phosphinechalcogenide1 (1.00 mmol) and carbaldehyde2 or 4 (1.05 mmol) in toluene(2 ml) was stirred at 23-50 C for 6 to 94 h in argon atmosphere (seeOnline Supplementary Materials for details). Toluene was removed undervacuum, and the residue was washed with Et2O (1 ml), dissolved in CHCl3and re-preciptatedwith n-hexane. The resulting solid was collected, driedunder vacuum to afford alcohols 3 or 5.<\/p>\n

The synthetic route of 27258-33-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 27258-33-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[160,131],"tags":[126],"class_list":["post-3451","post","type-post","status-publish","format-standard","hentry","category-27258-33-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 1-Methyl-1H-pyrazole-5-carbaldehyde<\/title>\n<meta name=\"description\" content=\"27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-Methyl-1H-pyrazole-5-carbaldehyde\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3451\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 1-Methyl-1H-pyrazole-5-carbaldehyde\" \/>\n<meta property=\"og:description\" content=\"27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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