{"id":3446,"date":"2021-04-15T05:46:18","date_gmt":"2021-04-14T21:46:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3446"},"modified":"2021-04-15T05:46:18","modified_gmt":"2021-04-14T21:46:18","slug":"a-new-synthetic-route-of-tert-butyl-4-amino-1h-pyrazole-1-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3446","title":{"rendered":"A new synthetic route of tert-Butyl 4-amino-1H-pyrazole-1-carboxylate"},"content":{"rendered":"

Electric Literature of 1018446-95-1<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

To a microwave tube was added 4-bromo-2-(2, 6-dichlorophenyl)-lH-imidazo-[4,5- c]-pyridine (0.050 g, 0.15 mmol), tert-butyl-4-amino-lH-pyrazole-l-carboxylate (0.032 g, 0.17 mmol), Pd2(dba)3 (0.013 g, 0.015 mmol), XantPhos (0.017 g, 0.03 mmol), Cs2C03 (0.098 g, 0.03 mmol) and dioxane (1.2 niL). The mixture was degassed with N2 for 1 min. The resulting mixture was irradiated in a microwave reactor at 160 C for 2 housr and then cooled to room temperature. The mixture was filtered with Celite and the filtrate was concentrated by vacuum. The residue was purified by prep-HPLC (Gilson GX 281 , Shim- pack PRC-ODS 250 mm x 20 mm x 2, gradient: CH3CN \/ 10 mm\/L NH4HC03, 17 min) to give the desired product (15 mg, 15% yield). ? NMR(MeOD- 4, 500 MHz): delta 8.09 (s, 1H), 7.90 (d, J = 5.5 Hz, 1H), 7.76 (s, 1H), 7.59 (m, 3H), 6.97 (d, J = 5.5 Hz, 1H). LCMS(ESI) m\/z: 345.2 [M+H+].<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[238,131],"tags":[126],"class_list":["post-3446","post","type-post","status-publish","format-standard","hentry","category-1018446-95-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of tert-Butyl 4-amino-1H-pyrazole-1-carboxylate<\/title>\n<meta name=\"description\" content=\"Electric Literature of 1018446-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3446\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of tert-Butyl 4-amino-1H-pyrazole-1-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 1018446-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of tert-Butyl 4-amino-1H-pyrazole-1-carboxylate","description":"Electric Literature of 1018446-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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