{"id":3441,"date":"2021-04-15T05:46:18","date_gmt":"2021-04-14T21:46:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3441"},"modified":"2021-04-15T05:46:18","modified_gmt":"2021-04-14T21:46:18","slug":"simple-exploration-of-3-amino-5-4-phenoxyphenylpyrazole-4-carbonitrile-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3441","title":{"rendered":"Simple exploration of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile"},"content":{"rendered":"

Related Products of 330792-70-6<\/a>, A common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

[0179] To a solution of (E)-N-(3-(3-(dimethylamino)acryloyl)phenyl)acetamide (46 mg, 0.2mmol) in HOAc (5 mL) was added 5-amino-3-(4-phenoxyphenyl)-IH-pyrazole- 4-carbonitrile(55 mg, 0.2 mmol). The mixture was stirred at 118 DC for 4 hr. Then the reaction mixture wasconcentrated to a residue and partitioned between ethyl acetate (100 mL) and brine (100 mL).Organic layer was separated, washed with brine (2×100 mL), dried over sodium sulfate andconcentrated to afford 80 mg (90percent) of N-(3-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[l,5-a]pyrimidin-7-yl)phenyl)acetamide as a colorless oil. MS (ESI) m\/e [M+ It 446.<\/p>\n

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[192,131],"tags":[127],"class_list":["post-3441","post","type-post","status-publish","format-standard","hentry","category-330792-70-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSimple exploration of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile<\/title>\n<meta name=\"description\" content=\"Related Products of 330792-70-6, A common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile\" \/>\n<meta property=\"og:description\" content=\"Related Products of 330792-70-6, A common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-14T21:46:18+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441\",\"name\":\"Simple exploration of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-14T21:46:18+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 330792-70-6, A common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3441#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Simple exploration of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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