{"id":3418,"date":"2021-04-15T05:45:39","date_gmt":"2021-04-14T21:45:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3418"},"modified":"2021-04-15T05:45:39","modified_gmt":"2021-04-14T21:45:39","slug":"extended-knowledge-of-1-4-fluorophenyl-5-methyl-1h-pyrazole-4-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3418","title":{"rendered":"Extended knowledge of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 217073-76-2, name is 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid<\/a><\/p>\n

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1-H)-one (0.100 g, 0.41 mmol), 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (0.0.99 g, 0.45 mmol), pyridine (0.15 mL, 1.83 mmol) in acetonitrile (4 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.61 mL, 1.02 mmol). The sealed tube was heated to 100 C. for 16 h. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile\/water to give 1-(4-fluorophenyl)-5-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-4-carboxamide (0.111 g, 61%). 1H NMR (400 MHz, DMSO-d): delta 12.43 (bs, 1H), 10.19 (s, 1H), 8.58 (s, 1H), 7.74 (m, 1H), 7.69 (dd, 1H, J=8.4, 2.0 Hz), 7.63 (m, 2H), 7.48 (s, 1H), 7.44 (m, 2H), 6.90 (d, 1H, J=8.0 Hz), 2.93 (t, 2H, J=7.2 Hz), 2.57 (s, 3H), 2.50 (partial masked under d-DMSO, in, 2H); MS (ESI): Calcd. For C23H18FN5O2S: 447 found 448 (M+1)+.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412,131],"tags":[127],"class_list":["post-3418","post","type-post","status-publish","format-standard","hentry","category-217073-76-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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