{"id":3404,"date":"2021-04-14T06:45:37","date_gmt":"2021-04-13T22:45:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3404"},"modified":"2021-04-14T06:45:37","modified_gmt":"2021-04-13T22:45:37","slug":"new-learning-discoveries-about-4-iodo-1-methyl-1h-pyrazole-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3404","title":{"rendered":"New learning discoveries about 4-Iodo-1-methyl-1H-pyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H5IN2<\/a><\/p>\n

Reference Example 140 tert-butyl ({4-(2-fluorophenyl)-5-[(1-methyl-1H-pyrazol-4-yl)thio]-1,3-thiazol-2-yl}methyl)methylcarbamate To a solution of 2-ethylhexyl 3-{[2-{[(tert-butoxycarbonyl)(methyl)amino]methyl}-4-(2-fluorophenyl)-1,3-thiazol-5-yl]thio}propanoate (356 mg) in ethanol (4 mL) was added sodium ethoxide (89 mg) at 0 C., and the mixture was stirred at room temperature for 1 hr, and concentrated under reduced pressure. A mixture of the residue, 4-iodo-1-methyl-1H-pyrazole (155 mg), tris(dibenzylideneacetone)dipalladium(0) (32 mg) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthine (39 mg) was stirred in toluene (5 mL) at 80 C. for 2 hr. The reaction mixture was allowed to cool to room temperature, water was added, and the mixture was extracted with ethyl acetate. The extract was washed successively with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: hexane-ethyl acetate=1:1) to give the title compound as a yellow oil (208 mg, yield 27%). 1H-NMR (CDCl3) delta: 1.46 (9H, brs), 2.94 (3H, brs), 3.85 (3H, s), 4.58-4.62 (2H, m), 7.15-7.26 (2H, m), 7.37-7.44 (3H, m), 7.48-7.53 (1H, m).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162,131],"tags":[127],"class_list":["post-3404","post","type-post","status-publish","format-standard","hentry","category-39806-90-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew learning discoveries about 4-Iodo-1-methyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H5IN2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3404\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New learning discoveries about 4-Iodo-1-methyl-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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