{"id":3402,"date":"2021-04-14T06:45:37","date_gmt":"2021-04-13T22:45:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3402"},"modified":"2021-04-14T06:45:37","modified_gmt":"2021-04-13T22:45:37","slug":"extended-knowledge-of-4-bromo-35-dimethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3402","title":{"rendered":"Extended knowledge of 4-Bromo-3,5-dimethylpyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 3398-16-1<\/a><\/p>\n

with reflux condenser and magnetic force to the rotor of the dry three-mouth bottle is sequentially added in the 3, 5 – dimethyl -4 – brompyrazole (5250 mg, 30 . 00 mmol, 1 . 00 equivalent), cuprous iodide (572 mg, 3 . 00 mmol, 0 . 10 equivalent), L – proline (690 mg, 6 . 00 mmol, 0 . 20 equivalent), potassium carbonate (8280 mg, 60 . 00 mmol, 2 . 00 equivalent) replacing nitrogen three times, then adding iodine anisole (10500 mg, 45 . 00 mmol, 1 . 50 equivalent) and steams again dimethyl sulfoxide (10 ml). The reaction mixture to the 120 C under stirring 2 days, TLC thin layer chromatographic monitoring until the raw material 4 – brompyrazole reaction finishes. The addition of water (100 ml) quenching the reaction, filtration, 50 ml ethyl acetate full washing insolubles, separating the mother liquor in the organic phase, dried with anhydrous sodium sulfate, filtered, the solvent removed by reduced pressure distillation. The obtained crude product through the silica gel column chromatography separation and purification, eluent (petroleum ether\/ethyl acetate=20:1 – 10:1), to obtain compound 1 colorless viscous liquid 8350 mg, yield 99%.<\/p>\n

The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,131],"tags":[126],"class_list":["post-3402","post","type-post","status-publish","format-standard","hentry","category-3398-16-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 4-Bromo-3,5-dimethylpyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 3398-16-1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3402\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extended knowledge of 4-Bromo-3,5-dimethylpyrazole\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Extended knowledge of 4-Bromo-3,5-dimethylpyrazole","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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