{"id":3394,"date":"2021-04-14T06:45:37","date_gmt":"2021-04-13T22:45:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3394"},"modified":"2021-04-14T06:45:37","modified_gmt":"2021-04-13T22:45:37","slug":"a-new-synthetic-route-of-diethyl-35-pyrazoledicarboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3394","title":{"rendered":"A new synthetic route of Diethyl 3,5-pyrazoledicarboxylate"},"content":{"rendered":"<p>37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. <a href=\"https:\/\/www.ambeed.com\/products\/37687-24-4.html\">SDS of cas: 37687-24-4<\/a><\/p>\n<p>A mixture of 2-bromo-1-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)ethanone hydrobromide (Intermediate 28A, 1.77 g, 3.2 mmol, 63% purity), diethyl 1H-pyrazole-3,5-dicarboxylate (642 mg, 3.0 mmol) and potassium carbonate (2.09 g, 15.1 mmol) in acetone (40 ml) was stirred overnight at room temperature. The solids were filtered off, and the filtrate was concentrated under re- duced pressure. The residue was purified by flash-chromatography on silica gel (eluent: petrole- um ether\/ ethyl acetate 2:1) to give 1.18 g (96% of theory) of the title compound. LC\/MS [Method 14]: Rt = 1.21 min; MS (ESIpos): m\/z = 402 [M+H]+. 1H-NMR (300 MHz, DMSO-d6): d [ppm] = 7.44 (s, 1H), 7.28-7.33 (m, 2H), 6.83 (d, 1H), 6.06 (s, 2H), 4.36-4.45 (m, 4H), 4.28 (q, 2H), 3.28-3.31 (m, 2H), 2.92 (s, 3H), 1.40 (t, 3H), 1.31 (t, 3H).<\/p>\n<p>The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[291,131],"tags":[127],"class_list":["post-3394","post","type-post","status-publish","format-standard","hentry","category-37687-24-4","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new synthetic route of Diethyl 3,5-pyrazoledicarboxylate<\/title>\n<meta name=\"description\" content=\"37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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