{"id":3385,"date":"2021-04-14T06:45:37","date_gmt":"2021-04-13T22:45:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3385"},"modified":"2021-04-14T06:45:37","modified_gmt":"2021-04-13T22:45:37","slug":"the-important-role-of-5-chloro-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3385","title":{"rendered":"The important role of 5-Chloro-1H-pyrazol-3-amine"},"content":{"rendered":"

Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine<\/a><\/p>\n

A solution of ie\/ -butyl (4S)-4-methoxy-3-oxo-pentanoate (1.96 g, 9.7 mmol) in DMF-DMA (1.25 mL) was heated at 120 C for 1 hour, then cooled to 80 C, and a solution of 3-chloro-lH-pyrazol-5-amine (1.14 g, 0.97 mmol) in EtOH (12.5 mL) was added. The resulting mixture was stirred for 2 hours at 80 C, then concentrated under reduced pressure. The residue was purified by silica chromatography (hexane: EtOAc= 5: 1 to 1: 1) to give the title compound (1.60 g, 53%). 1H NMR (400 MHz, DMSO-J6): delta 8.66 (s, 1H), 7.05 (s, 1H), 5.26 (q, 1H), 3.22 (s, 3H), 1.62 (d, 3H), 1.56 (s, 9H). MS m\/z 312.24 [M+H]+.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 916211-79-5, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 916211-79-5, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[528,131],"tags":[126],"class_list":["post-3385","post","type-post","status-publish","format-standard","hentry","category-916211-79-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 5-Chloro-1H-pyrazol-3-amine<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 5-Chloro-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-13T22:45:37+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385\",\"name\":\"The important role of 5-Chloro-1H-pyrazol-3-amine\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-13T22:45:37+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3385#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 5-Chloro-1H-pyrazol-3-amine\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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