{"id":3374,"date":"2021-04-13T00:00:00","date_gmt":"2021-04-12T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3374"},"modified":"2021-04-13T00:00:00","modified_gmt":"2021-04-12T16:00:00","slug":"the-origin-of-a-common-compound-about-ethyl-3-methoxy-1h-pyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3374","title":{"rendered":"The origin of a common compound about Ethyl 3-methoxy-1H-pyrazole-4-carboxylate"},"content":{"rendered":"

Application of 478968-48-8<\/a>, A common heterocyclic compound, 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

[0765] A mixture of ethyl 3-methoxy-1H-pyrazole-4-carboxylate (200 mg, 1.18 mmol), CuT (23 mg,0.12 mmol), L-proline (28 mg, 0.24 mmol), 5-bromo-2-(trifluoromethyl)pyrimidine (320 mg, 1.41mmol), and potassium carbonate (407 mg, 2.95 mmol) in N,N-dimethylformamide (6 mL) was stirredovernight at 100C under nitrogen. The solid was filtered out and the liquid was concentrated. Theresidue was purified by a silica gel colunm eluting with dichloromethane to afford the title compound(210 mg, 57%) as a light yellow solid. LCMS [M+H]317; ?H NMR (300 MHz, CDC13) 3 9.21 (s, 2H),8.40 (s, 1H), 4.39-4.32 (m, 2H), 4.12 (s, 3H), 1.38 (t, J= 7.2 Hz, 3H).<\/p>\n

The synthetic route of 478968-48-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 478968-48-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[527,131],"tags":[126],"class_list":["post-3374","post","type-post","status-publish","format-standard","hentry","category-478968-48-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about Ethyl 3-methoxy-1H-pyrazole-4-carboxylate<\/title>\n<meta name=\"description\" content=\"Application of 478968-48-8, A common heterocyclic compound, 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about Ethyl 3-methoxy-1H-pyrazole-4-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Application of 478968-48-8, A common heterocyclic compound, 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-12T16:00:00+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374\",\"name\":\"The origin of a common compound about Ethyl 3-methoxy-1H-pyrazole-4-carboxylate\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-04-12T16:00:00+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 478968-48-8, A common heterocyclic compound, 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3374#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The origin of a common compound about Ethyl 3-methoxy-1H-pyrazole-4-carboxylate\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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